Fentanyl is a synthetic narcotic analgesic of high potency and short duration of action. Though 200 times more potent than morphine, fentanyl has a high safety margin. The drug is available as a citrate salt in an injectable solution containing 50 μg/mL. It is also available as a transdermal patch containing 2.5-16 mg fentanyl and provides a dose of 25-100 µg/hr for 72 hours for the management of chronic pain.
While fentanyl has all the properties of morphine, it is structurally different and therefore cannot be detected by screening tests for morphine and related opiates. Because of the potency of the drug, concentrations encountered in biological fluids are in the sub-nanogram range.
Administration: Intravenous, transdermal patch, flavored lozenges, lollipops, buccal tablets, nasal spray, and inhalant.
Elimination: Fentanyl plasma protein binding capacity decreases with increasing ionization of the drug. Fentanyl is metabolized primarily via the human cytochrome P450 3A4 isoenzyme system. In humans, the drug appears to be metabolized primarily by oxidative n-dealkylation to norfentanyl and other inactive metabolites that do not contribute materially to the observed activity of the drug. Within 72 hours of IV fentanyl administration, approximately 75% of the dose is excreted in urine, mostly as metabolites with less than 10% representing unchanged drug.
Abuse Potential: Fentanyl can be abused and is subject to criminal diversion. Mixing fentanyl with street-sold heroin or cocaine markedly amplifies potency and potential dangers. It produces significantly worse respiratory depression and non-medical use of fentanyl has resulted in numerous deaths.
Storage Temp: 2-8°C
| Quantity | Each |
|---|---|
| Hazardous | No |
| Is Featured | No |
